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深圳市豪地华拓生物科技有限公司品牌商
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深圳市豪地华拓生物科技有限公司
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丁先生
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广东 深圳市 南山区
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MMP-9 Antibody
574 人阅读发布时间：2016-08-22 16:56
MMP-9 Antibody
【点击查看详细说明书及图片】
Product Subcategory：Rabbit Polyclonal Antibody
Cat. No：250755
Unit：0.1 mg
Isotype：Rabbit Ig
Accession No：P14780
Applications：E, WB, IHC
Species Reactivity：H, R, GP
Application Notes：Product Cat. No. 250755 does not react with mouse MMP-9. E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500
Antigen：KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human MMP-9.
Format：Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Alternate Names：Matrix metalloproteinase-9; MMP-9; 92 kDa type IV collagenase; 92 kDa gelatinase; Gelatinase B; GELB
Storage：Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Description：
Matrix metalloproteinase protein family (MMP) is involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction, and tissue remodeling, as well as in diseases such as arthritis and metastasis. Most MMPs are secreted as inactive precursors which are activated upon cleavage by extracellular proteinases. MMP-9 is an enzyme that degrades gelatin types I and V, and collagen types IV and V, and KiSS1. MMP-9 has an essential role in local proteolysis of the extracellular matrix, in leukocyte migration and possibly in bone osteoclastic resorption. MMP-9 exists as a monomer, disulfide-linked homodimer, and as a heterodimer with a 25-kDa protein. Macrophages and transformed cell lines only produce the monomeric form. Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Defects in MMP-9 may be a cause of susceptibility to lumbar disk herniation (LDH), a predominant cause of low-back pain. MMP-9 could be a disease status marker in arthritis patients.
Product Citations
[1] Agabiti-Rosei C et al. 2014. J.Hypertens. 32(6): 1264-1274. PMID# 24751595. [2] Ambalavanan N et al. 2013. American Journal of Physiology-Lung Cellular and Molecular Physiology. 304(3):L152-L161. PMID# 23220372. [3] Li X et al. 2011. Medical Oncology. 29(2): 714-720. PMID# 21431960. [4] Pina Y et al. 2010. Investigative Opthalmology and Visual Science. 51:2671-2677. PMID# 20053982. [5] Bajenaru M et al. 2010. Investigative Opthalmology and Visual Science. 51: 2860-2864. PMID# 20107171.
MMP-9 staining in lung carcinoma. Formalin-fixed paraffin-embedded human lung carcinoma tissue is stained with MMP-9 Antibody (Cat. No. 250755) used at 1:200 dilution.
ABBIOTEC公司位于生技圣地--美国圣地亚哥，是2007年新成立的一间生物技术公司，其产品在生命科学实验有着广泛的应用；Abbiotec公司专注于开发抗体，多肽，蛋白等试剂和使其不断市场化；Abbiotec的专有技术使其能够高效的挑选，设计和生产抗体，裂解物，以及各种试剂，让研究人员能够更专注于他们的研究。高质量、创新与完整的产品、合理的价格为Abbiotec不变的坚持与承诺；Abbiotec将不断为满足客户的需要和让他们获得最好的成果而努力。|